Memory loss

I'm new here guys. I joined this site because my husband and his sister both have PsA. My husband has had this for years. My sister -in - law just within the last 5 years. I believe they are on the same medication. Methotrexate and Prednisone.

Within the last 2 years we noticed my sister-in-law having short term memory loss. It got so bad her boss called us worried. I was worried about her getting to downtown Chicago on the train. My husband was in denial. Said she was not that bad. We told her to carry a notepad to write things down. But she would forget to carry the notepad. Within a month she was laid off her job. She has had MRI's, Ct scans and test after test to find the problem. They say she does not have dementia or Alzheimer. She is depressed, lost at least 50 lbs. This poor women is 56 yrs old and never left home. She still lives with her parents. So her life was depressing before all these problems. I think she is just giving up. I tried to talk her into taking anti - depressants. She refuses. we tried to get her to use the computer to stimulate her mind. Refuses. She just had another MRI. The doctor said the memory loss was just old age. That's just crazy at 56.

Now I'm noticing my husbands short term memory loss. I will tell him things and he swears I never told him. Driving is beginning to be a problem. He goes the wrong way or misses a turn. He say's he is just not concentrating. His problem is not as bad as his sisters although he is 2 yrs older. I contribute this to several factors. First he is male, his job keeps his mind active(accountant), he is in very good physical shape, goes to the gym several times a week.

So I'm thinking dementia for both of them. Even though the doctors say no. No family history of dementia or Alzheimer. I just thought about them both having PsA. So I googled it. There does not seem to be much evidence memory loss and PsA are related. That's what brought me here. I told me husband I was going to this site and he got upset. Swears he has no problem. But his mother brought up the fact she is noticing he is forgetful.

I would appreciate any information. thanks

I don't know much about PsA, however, I do have memory loss and have for some years. I am only 37, my family swears I have early signs of Alzheimer's. I appreciate this question, as I have wondered if there was a connection.

Thanks for posting and I'm sorry I can't be of more help to you. Good luck with your husband and sister-in-law.

Welcome! You have found the right site. My brother and I have PsA and I suspect that my stubborn nephew has it as well. While I am by no means an expert, I think that prednisone sometimes causes short term memory problems. The only thing I can blame on PsA is fatigue and brain fog. The memory is there and I have the right words, but I can't make them come out of my mouth, so a lot of times what ever I am talking about becomes a "thing". I would encourage your sister-in-law and your husband to join this group. They can see that they aren't alone and talking to others just makes life with PsA much more bearable. It is wonderful that you are helping them.

Hi there, Windy City.

As grumpy as he is about it, it mostly likely wouldn't hurt to sit him down (with his Mom present) and explain your concerns. Having MRIs are good and all, but they really need to see a neurologist-really that's the specialist needed to diagnose any memory loss issues.

Here's some links I've found regarding chronic inflammatory disease and memory loss.

https://www.ucsf.edu/news/2011/04/9712/ucsf-study-links-inflammation-brain-some-memory-decline

http://www.theglobeandmail.com/life/health-and-fitness/advsunnybrook/sunnybrookfeatures/memory-loss-caused-by-inflammation-may-be-reversible/article4563078/

And by the way, your sister in law's doctor is wrong. It is not normal to lose memory as you age. That's a myth: http://www.psychologytoday.com/blog/health-matters/201101/memory-matters

When I was first being diagnosed with an AI condition, I was so fatigued, I didn't even realize it at the time until I started to get treatment. I have always been pretty quick to come up with what I want to say, quick on my feet I guess. I noticed I started to have problems spitting out what I wanted to say, words would come out wrong like "offer" instead of "outfit" or something similar. I'm 38 now, so this was happening when I was 36-37. My rheumatologist asked me if I had a history in my family of dementia, I don't that I know of. She kind of blew that off, but I kept on complaining about the fatigue. She prescribed 1 mg per day of folic acid to help with the MTX side effects, I take the max dose. I could have been on pred at the time, I'm not any more. Now I take 2 mg of folic acid every day, I kept after her about the fatigue. I think the fatigue gets so bad it fogs your brain, personally. I'm on Cimzia now and even on Humira, my thinking snapped back into place. I have also been doing online brain training because memory loss freaked me out! So hopefully what they are experiencing can be reversed but I wouldn't ignore it.



Sunny said:

Hi there, Windy City.

As grumpy as he is about it, it mostly likely wouldn't hurt to sit him down (with his Mom present) and explain your concerns. Having MRIs are good and all, but they really need to see a neurologist-really that's the specialist needed to diagnose any memory loss issues.

Here's some links I've found regarding chronic inflammatory disease and memory loss.

https://www.ucsf.edu/news/2011/04/9712/ucsf-study-links-inflammatio...

http://www.theglobeandmail.com/life/health-and-fitness/advsunnybroo...

And by the way, your sister in law's doctor is wrong. It is not normal to lose memory as you age. That's a myth: http://www.psychologytoday.com/blog/health-matters/201101/memory-ma...



WindyCity said:



Sunny said:

Hi there, Windy City.

As grumpy as he is about it, it mostly likely wouldn't hurt to sit him down (with his Mom present) and explain your concerns. Having MRIs are good and all, but they really need to see a neurologist-really that's the specialist needed to diagnose any memory loss issues.

Here's some links I've found regarding chronic inflammatory disease and memory loss.

https://www.ucsf.edu/news/2011/04/9712/ucsf-study-links-inflammatio...

http://www.theglobeandmail.com/life/health-and-fitness/advsunnybroo...

And by the way, your sister in law's doctor is wrong. It is not normal to lose memory as you age. That's a myth: http://www.psychologytoday.com/blog/health-matters/201101/memory-ma...

Sunny, thank you so much for your response. All the information is extremely helpful. I'm pretty sure it was the neurologist who said the memory loss was aging. I'm printing all the articles to give to them. thanks again

Dear Windy City, I'm so glad you found us! Being the pillar of support in a family of people with a chronic and frequently misunderstood disease is not an easy job! This online support group was designed not just for people with PsA, but also for their support network (family, friends, caregivers, etc). Sometimes denial runs strong, and if you can't talk about it with the person who has the disease, you need a place where you can come and ask questions and find real information. That is what we are here for.

I used to have a job that kept me "engaged." I was the CEO of a midsize nonprofit organization (an adult education and cultural arts center) that served more students and offered more programs with less money than any other adult education center in the country. We were nationally recognized as a model for adult education programs. It was a great job but full of stress. When I was a kid, I was incredibly unorganized and unfocused, but everyone assumed it was because I was creative and had my "head in the clouds." That was partly true. I also think it was the first manifestation of PsA for me. After I grew up and "got a real job," I was able to buckle down and focus. I became almost regimental in my ability sort order out of chaos. I wrote grants, reported on grants, ran the day to day operations, collected data, organized that data into spreadsheets and databases that were easily searchable, etc. etc. When my brain started fogging over, no one (including me) recognized what it was - it became kind of a running joke when I would start drifting off during presentations onto tangents, or misplacing things, or forgetting what word I meant to use in a sentence. The staff and I would laugh, and get back on track and things would go on. Unfortunately it began to become more frequent. I started forgetting important meetings, even though they were on my Google calendar, my desk calendar, and on the multiple lists I created at the end of each day for the next day's work plan. So I took a pay cut so I could hire a part time administrative assistant to help me keep organized. Again, it seemed like I was just overwhelmed with all the things I had to do (I was working 80-120 hours a week, and hadn't had a vacation in 7 years). Even when I got diagnosed with PsA, it didn't click. I knew I was getting sicker. My psoriasis was out of control, my joints were incredibly inflamed and ouchie, My typing ability went from 90 words a minute with no errors to hunt-and-peck. But I was on medications, and I was determined to continue doing what I needed to do. I was silly enough to think I was the ONLY person who could do my job successfully (actually, it turns out that was correct, but that is another story for another day). Finally, when 2 staff secret love affairs imploded and the whole organization was rocked with 2 back-to-back sexual harassment claims (both were sour grapes, but had to be fully investigated because of the secrecy of the then failed love affairs), it became obvious to me and to a lesser degree to the board of directors, that I wasn't all there. I finally stepped down because it was becoming increasingly difficult to do everything that needed to be done when I kept forgetting things, losing lists, forgetting to input data into the databases and spreadsheets, etc. This all finally came to a head a few weeks ago when my husband found me crying in the kitchen with an onion in one hand, a sharp knife in the other, and not able to figure out what the knife was for. It took me 20 minutes to quarter an onion, and then only happened because my husband took over making dinner and encouraged me to go lay down. I had already spoken to doctors about it (I didn't quit my job without trying to figure out what was wrong with my head), and had had several tests that were completely inconclusive. I didn't figure the problem completely out until two things happened: 1) My mom was diagnosed with late stage colon cancer, and began exhibiting the exact same form of brain freeze when she started chemotherapy, and 2) I came on here and started reading about other people with PsA having brain freeze (or as I affectionately call them Brain Farts). I can't tell you definitively whether they are from the meds or from the PsA, but there is certainly a correlation between those two factors and dementia/early onset alzeimer's- type symptoms. The good news is, your husband, his sister and YOU are not alone. The bad news is, there isn't a cure, nor do doctors even recognize the need for one. BUT, the other good news is, there are things you and he can do to make adaptations so that those forgetful moments don't ruin your lives. Make lists. Make lots and lots of lists. Write down, and keep handy, simple step by step instructions for things he has to do every day that he might have trouble with. The most important thing you guys can do, though, is to communicate. I don't know you, him, or the dynamics of your relationship, so I can't tell you how to begin the communication process, but both of you need to figure out how to let him acknowledge what is happening in a way that feels safe and non-confrontative. Once he begins to admit to you (and most importantly to himself) that there is a problem, you can encourage him to come on here and begin reading. He doesn't even have to begin with doing anything more than a simple introduction on the new members introduction place. He can then start scrolling through the various discussions. This brain-freeze type thing comes up pretty regularly. Once he realizes he isn't alone in this fight, hopefully he will be able to start talking to you about it. Eventually he will realize that we are all normal people in extraordinary circumstances, and we are all here to support and encourage each other without judgement, and he just might start asking questions here also.

Good luck, keep on this site reading and learning. It could change your life in positive ways you can't possibly imagine. It certainly did mine!

Dear Windy,

PLEASE:-)Don't Scream Alzheimer's so darn fast------- this is coming from one who has been down that diagnostic road. It is demoralizing in more ways than you can possibly imagine if you have not been there. I had the same symptoms as those you describe. Turned out to be.... PsA, inflamed by Strep virus becoming Ankelyting Spondalitis in my neck/brain stem and also surrounding a nerve bundle in my lower back that was damaged in an MVA twenty years ago. I just found out last week after three years!!!

My family did this to me. It started as a joke and then became an issue and the next thing I know I was in the mental ward because I wanted to die rather than face Alz. It took three years, seven Doctors, suicidal institutionalization and nearly a divorce to get them to realize I was ill, not crazed with dementia. A SIMPLE BLOOD TEST WOULD HAVE HELPED!!!!!!!!!!! I am now on the road to recovery thanks to a good Reumatologist, Neurologist, Dermatologist, Optomologist( that was on the ball )and a real GP not a PAC. I have Migraines so bad I am losing brain function and I have nerve damage, not Dementia or Alzheimer's. I have started my PsA regime and am on my way to neuro mapping ASAP then an MRI for function.... then probably surgery if that is what the Neuro wants as I have very little feeling left in feet and legs.

This thing has been in my family for as long as I can remember and my gram was tagged with Alz and all she really wanted was relief from the brain fog and itch! Please ... treat them with kindness, they cannot help the way they are now and they do not want to be that way. I am quite sure they hate it as much or more than you do. GEt them help and slowly lead them through this site. send them to my blogs, it may help to know they are not alone. I am the crazy one with the loud mouth that always gets herself in trouble!!!!!!!

Hugs your way kiddo, you need them, you can do this , we will hold you up! .... try to stay warm today XXXXXXXXX

I am in agreement with pretty much everything tmbrwolf329 posted. I wish to add to what has already been said. I too have had some of the brain fog which was more prevalent when I was fatigued and before or early in treatment. I have not been on Prednisone. Ten and a half yrs. ago I had a sudden (so it seemed) onset of severe hypersensitivity to salicylates which includes all NSAIDs (non-steroidal anti-inflammatory drugs) and even foods that naturally contain it. In hind sight it appears that I had earlier signs of impending autoimmune system issues which ultimately relates to PsA. For some people they may be an undiagnosed ADD or ADHD (which can be caused entirely or partially by salicylates and artificial colors and preservatives). In the case of some there is some potential of ADHD not diagnosed and thus when people try the first line of medication for PsA (NSAIDs) they may be aggrevating an independent issue (ADHD). Depression is also an accompanying symptom of ADD/ADHD. Many chronic conditions cause depression and some of it may be biological directly from the chronic condition and absolutely from the emotional wear and tear of the limitations, pain, and adjustments one faces. Depression can very much look a lot like dementia.

So all this leads to a more complex look at the brain fog rather than it be only due to PsA but certainly including it. A lot of foods I cannot eat due to the hypersensitivity/allergy to salicylates which are seen as anti-inflammatory diet. A person with ADD/ADHD or other condition sensitive to salicylates who follows an anti-inflammatory diet and meds may be adding to the symptoms rather than helping.

I wish life were easier but looking for one singular answer to an issue is often less than complete.

I gotta agree with Dr. Marc- depression can cause some memory issues as can fatigue. Speaking of, have they had their vitamin D levels checked? Turns out quite a bit of us are low on D and that can worsen fatigue.

I want to toss in here that I just saw my rheumy today, and one of the standard questions on the health questionnaire is memory, with a scale of poor memory to excellent memory. I don't think it would be on there if there wasn't some connection with various rheumatological diseases.

You know everyone is different whether it's the disease or the medication reactions.

For me Mtx was the culprit of so many side effects, one of them being memory loss and in general just not being able to concentrate. While I was on it I couldn't remember things I had done at the same job for 10 years...before that things were automatic, like riding a bike. This symptom along with others disappeared after I stopped taking mtx. I was reaching a point where I thought I might lose my job because I was forgetting very important but standard things that were part of my job. It was scary.

Others will tell you different where mtx is concerned but this is my experience. Some people have no side effects from it at all. It's always possible it's a combination of factors that are contributing to the memory loss. Best of luck. I hope they appreciate you wanting to help.

Hello

I have PsA and fibro. When I have a flare I have noticed my memory loss is horrific. When the flare goes down my memory gets a bit better but I do not believe it is as good as it used to be. I have begun taking a few vitamins and that seems to help.