I was diagnosed with PSA and psoriasis four years ago. My psoriasis is not that bad but my PsA is very severe. I have been on Humira, until it started to cause burning in my hands and feet, I briefly tried Enbrel but started to get headaches.
One of my most recent drugs was Cimzia. It worked great for the first 5 months but then started to completely wear off. I was taking my Cimzia injection once every two weeks. About 5 months into it, I noticed my pain would come back a day before the next injection. Then, during the next injection period, the pain would come back after 8 days. Then, during the next injection period, the pain would come back after 6 days. Then, 1 day. My rheumatologist switched me to Simponi. I took Simponi and the very next day, I felt like 80% better, but the following day, my pain started to come back. I have been on Simponi for a little over three weeks and I am still getting worse. I don’t think it is working. I told my rheumatologist about what Simponi is doing and he said that we can try Remicade or something that is not a TNF-a blocker. He said that it is possible that my body is not absorbing the injection and that an infusion based drug like Remicade might help.
I am getting in pretty bad shape and not sure how much longer I can continue to work. Should I try Remicade or do you think my time with TNF-a blockers has come to an end?