I take 17 .5 once a week and always have a headache. I think it’s my neck though. Never thought it could be the methotrexate.
Never thought it could be heat related either.
anybody else have this problem.

Under 'what you should know' it tells you about exposure to heat, sunlight, tanning beds while taking this med. I took it during the cooler months, so did not experience it, but remembered it from the precautions.

Please feel better soon!


I get a horrible headache EVERY time I take methotrexate. I take 6 pills every sunday . I usually try to split my does in half 3 in the am and 3 in the afternoon. I take it on the same day. I have been on it for 3 years , I suppliment it with Remicade every 4 weeks. The HEAT is awful . I feel like sometimes I get a sunburn on my face from it and Im not even in the sun !!!!