I find this discussion really interesting. My own thoughts are almost everyone at the relative beginning of their journey of being medicated for PsA, is utterly thrown by the apparent toxcity of the drugs used to treat it. Most, though not all, have already endured quite a journey to get the diagnosis of PsA anyway. Those who were diagnosed quickly (I was one of them) are in total shock though of the diagnosis, though. So either way, each of us has been dealt with something of a body blow including psychologically regardless.
Those who have waited for a diagnosis are enduring the damage it’s already caused to various bits of their body, and those of us diagnosed quickly are still getting our heads around the fact it can cause such frankly awful damage.
And then wham in comes mxt in almost everyone’s individual experience. There appears to be very few of us who don’t suffer at least initial pretty debilitating side effects from it which appears in addition to the already present horrible effects of PsA. Some though are really lucky and don’t. And some are lucky in that those side effects ease quickly. Some however aren’t that lucky though and truly struggle with the added effect of mxt on them. And of course it’s a slow acting drug so it can take several long weeks or months to actually do anything positive for the PsA.
When that happens some people think to themselves yes it helps my PsA so I can put up with how it additionally makes me feel, and some though just can’t think that.
Throughout all of this time though our individual psyches can feel horrendously battered. And often it’s a long journey then to get switched on to a med that doesn’t produce side effects like mxt can do but also positively treats and/or curtails the PsA.
As others on here will know it took me quite some time to be able to accept PsA needed these types of drugs, that’s the downside of being diagnosed quickly incidentally.
When I took mxt twice, the second time a year later, I simply couldn’t tolerate its side effects, The first time, I’ve no doubt I was a total drama queen about them, but the second time, I entered into taking it in a far better and far more resilient frame of mind. But neither time could I function on any level. So I’m with @Kutya on the need to be cognisant about ‘what they TAKE’. For me it was pointless taking a drug where its side effects made me require something on the lines of 24 hour care, whereas the then effects of PsA didn’t.
On the basis that I was properly congnisant of what it could ‘take’ from me, I was offered another DMARD which didn’t produce any noticeable side effects and which ended up working rather well for a time at least. And we’ll see shortly if it continues to do so as it’s just had something of a blip presently and I don’t know yet if that means it’s simply stopped working.
So for me I couldn’t function at all on mxt but certainly could on sulfasalazine. And when sulfsalazine then worked, boy was I then functioning just coherently. For me I’m eternally grateful I didn’t persist in enduring what the side effects of mxt did to my functional ability, even if that means sadly I’ll never experience its positive effects on my PsA either now or in the future.
I don’t have enough wealth monetary wise to be rendered incapable of earning my living by the side effects of drugs used to treat my PsA which has never stopped me yet of being able to work and remain employed.
I’m eternally grateful to this forum of teaching me to fear the disease more than its drugs, but as @Stoney says we each have to make our own choices. But personally I could never make that decision for a drug that rendered me as incapacitated as mxt did. I don’t see the point of life if it isn’t a coherent one.