First, I wanted to ask if the MTX was doing anything for you. It sounds like you've got the most symptom relief from Enbrel, but maybe I missed something.
It's been 13 days since my last Enbrel injection. Honestly, I don't think I'm having symptoms of PsA or psoriasis any worse (I always have about 20% of the symptoms I had before starting Enbrel). But Saturday night I did have some pain in my knees that I haven't had for a long time.....I'm hoping having the strep and taking penicillin is fending off any flares, though!
The doctor checked my WBCs when I went in for my strep. I had told him my rheumy was concerned about them. Interestingly, my WBCs were in the normal range--he said because of the strep, but they would go down again and I should still have them rechecked in September. This is so scary because, in the winter especially, it seems like at least one grandkid is sick at any given time, and I'm with them a lot. I was concerned Friday at work because my supervisor has a cold. I asked her to keep her distance, but she kept insisting she only had allergies. I hear of so many people on this site who said they caught what they thought was a cold and it ended up being pneumonia and they had to be in the hospital! That's so scary and something I wouldn't want!!!!!
I wouldn't worry about SEs from Enbrel, but I'm pretty sure people have experienced nausea from MTX. I get hot flashes, but I've been getting them since peri-menopause. I always chalked them up to that.
My stiffness left almost immediately when I started Enbrel. I was like you, slow to rise and start moving--I was like a 90-year old getting out of bed, a chair, etc. Everything was stiff, especially my lower back. Well, about 7 weeks after starting Enbrel, my new wonderful, limber back went out--and worse than ever! Someone mentioned maybe it went out because it wasn't used to all the new movement. That made sense to me. I had had back pain problems for a few years, but this was so extreme I was actually pretty much bedridden for several days on tons of ibuprofen and constant heating pad. After 3 weeks, and by that time the pain was a lot more bearable, an MRI showed a disc protrusion impinging my spinal cord, and several bulging discs. On top of that, my left SI joint has signs of AS...they were interested that my left SI wasn't giving me trouble at the time--the pain was in my right butt and leg. Well, in December my left SI did start hurting and that was horrible, too! THEN, around March 1st, my feet started killing me!!!!
So, beware of your new "loose" joints and, even though you feel really good, don't overdo it! Maybe you won't have these things happen to you, but better to be safe than sorry. I, in no way, feel as good as I did those first 7 weeks on Enbrel, but the pain is not PsA pain-it's all due to damage from PsA. All those years of having a stiff back and neuropathy in my feet did some damage that's irreparable. Ugh, but still better off with Enbrel--except now for the low WBCs and worrying about germs! Ugh!
I'm glad Enbrel is working for you--it's a miracle, isn't it? I wish it worked that well for everyone!