In terms of the co-morbidities and the biologics - there are a lot of indications, but it seems too early to be sure.
One of the most interesting ways I’ve found to research this subject was reverse research - so rather than look at PsA, look at anti TNF and see where that leads you. There have been quite a few studies I’d describe as aspirational, but there have certainly been some remarkable results for some of the co-morbidities, in the absence of PsA.
In addition, there’s been at least one or two studies showing, for remicade at least, significant improvement in radiographic scores (comparative to placebo) even among non responders. Yep - you heard me right, even if there is no clinical response detected;
http://www.ncbi.nlm.nih.gov/m/pubmed/15818697/
(Sorry, there is actually a much more robust study than this but I can’t seem to re-find it today).
I don’t bet with my money (I don’t need to). But I do need to make a choice for my health based on probabilities.
My bet is that lowering the inflammation will also reduce many if the risks for co-morbidity. It’s going to take you lots of time to do your own research on that, and get your own gut feeling though 