# Methotrexate questions **URL:** \ **Category:** General\ **Created:** [January 1, 2013, 10:00pm UTC](https://discussion.livingwithpsoriaticarthritis.org/t/methotrexate-questions/1284 "2013-01-01T22:00:12Z")\ **Posts on this page:** 10\ **Page:** 1
**Author:** ![NannyRed](https://sea1.discourse-cdn.com/flex019/user_avatar/discussion.livingwithpsoriaticarthritis.org/nannyred/32/879_2.png) [@NannyRed](https://discussion.livingwithpsoriaticarthritis.org/u/NannyRed)\ **Post date:** [January 1, 2013, 10:00pm UTC](https://discussion.livingwithpsoriaticarthritis.org/t/methotrexate-questions/1284/1 "2013-01-01T22:00:12Z")
I have been diagnosed with Psoriatic Arthritis and am taking methotrexate 2.5mg , 3tab 1 time a week. I have been on it for 1 month. The only real problem that I am having with the medication is that I itch constantly!! Does anyone else have this problem and if so do you have any suggestions for me? Thanks, Nanny Red ---
**Author:** ![Never\_give\_up\_hope](https://sea1.discourse-cdn.com/flex019/user_avatar/discussion.livingwithpsoriaticarthritis.org/never_give_up_hope/32/876_2.png) [@Never\_give\_up\_hope](https://discussion.livingwithpsoriaticarthritis.org/u/Never_give_up_hope)\ **Post date:** [January 2, 2013, 1:27am UTC](https://discussion.livingwithpsoriaticarthritis.org/t/methotrexate-questions/1284/2 "2013-01-02T01:27:46Z")
I don't take mtx,though all medications have side effects. I would talk to your doctor, with itching you may be allegic ---
**Author:** ![Stoney](https://sea1.discourse-cdn.com/flex019/user_avatar/discussion.livingwithpsoriaticarthritis.org/stoney/32/5959_2.png) [@Stoney](https://discussion.livingwithpsoriaticarthritis.org/u/Stoney)\ **Post date:** [January 2, 2013, 2:12am UTC](https://discussion.livingwithpsoriaticarthritis.org/t/methotrexate-questions/1284/3 "2013-01-02T02:12:41Z")
I don't remember if dry skin is a side effect of MTX. Could that be the cause of the itching? ---
**Author:** ![NannyRed](https://sea1.discourse-cdn.com/flex019/user_avatar/discussion.livingwithpsoriaticarthritis.org/nannyred/32/879_2.png) [@NannyRed](https://discussion.livingwithpsoriaticarthritis.org/u/NannyRed)\ **Post date:** [January 2, 2013, 3:31am UTC](https://discussion.livingwithpsoriaticarthritis.org/t/methotrexate-questions/1284/4 "2013-01-02T03:31:56Z")
I am thinking maybe that is it...along with the psorasis. Benadryl helps somewhat. Thanks for your reply!! Stoney said: > I don't remember if dry skin is a side effect of MTX. Could that be the cause of the itching? ---
**Author:** ![Margmotherof4](https://sea1.discourse-cdn.com/flex019/user_avatar/discussion.livingwithpsoriaticarthritis.org/margmotherof4/32/365_2.png) [@Margmotherof4](https://discussion.livingwithpsoriaticarthritis.org/u/Margmotherof4)\ **Post date:** [January 2, 2013, 6:09am UTC](https://discussion.livingwithpsoriaticarthritis.org/t/methotrexate-questions/1284/5 "2013-01-02T06:09:11Z")
I have been on mtx for a year now and am on 25mg per week and no itching at all. ---
**Author:** ![sixcatlawyer](https://sea1.discourse-cdn.com/flex019/user_avatar/discussion.livingwithpsoriaticarthritis.org/sixcatlawyer/32/913_2.png) [@sixcatlawyer](https://discussion.livingwithpsoriaticarthritis.org/u/sixcatlawyer)\ **Post date:** [January 3, 2013, 12:48am UTC](https://discussion.livingwithpsoriaticarthritis.org/t/methotrexate-questions/1284/6 "2013-01-03T00:48:02Z")
Itching can be a symptom of liver troubles. Have you had your first bloodwork done? How are your liver enzymes? Three things: 1) make sure you drink fluids the day before, day of and day after taking your dose. It will help your system "flush"; 2) talk to your doc about taking double the folic the day before and day after your dose; 3) I'm taking milk thistle, which is a natural supplement to support the liver. My bloodwork last week (on .6 cc injectable (25 mg, I think) MTX/week was better than in August or September. I don't know how much is attributable to being religious about taking my folic or to the milk thistle. I'm saying it was both. ---
**Author:** ![Rebel\_mom](https://sea1.discourse-cdn.com/flex019/user_avatar/discussion.livingwithpsoriaticarthritis.org/rebel_mom/32/585_2.png) [@Rebel\_mom](https://discussion.livingwithpsoriaticarthritis.org/u/Rebel_mom)\ **Post date:** [January 3, 2013, 1:20am UTC](https://discussion.livingwithpsoriaticarthritis.org/t/methotrexate-questions/1284/7 "2013-01-03T01:20:29Z")
I though you could notvtake milk thistle with mtx because it is an herb? ---
**Author:** ![Pookie](https://sea1.discourse-cdn.com/flex019/user_avatar/discussion.livingwithpsoriaticarthritis.org/pookie/32/662_2.png) [@Pookie](https://discussion.livingwithpsoriaticarthritis.org/u/Pookie)\ **Post date:** [January 3, 2013, 10:59am UTC](https://discussion.livingwithpsoriaticarthritis.org/t/methotrexate-questions/1284/8 "2013-01-03T10:59:56Z")
My advice would be to contact your doc, this itching could be an allergic reaction, I started on 3 tabs of MTX and am now on 10 and have never had any itching. Good luck x ---
**Author:** ![NannyRed](https://sea1.discourse-cdn.com/flex019/user_avatar/discussion.livingwithpsoriaticarthritis.org/nannyred/32/879_2.png) [@NannyRed](https://discussion.livingwithpsoriaticarthritis.org/u/NannyRed)\ **Post date:** [January 3, 2013, 2:51pm UTC](https://discussion.livingwithpsoriaticarthritis.org/t/methotrexate-questions/1284/9 "2013-01-03T14:51:27Z")
I want to thank you all for your replies!! I will be discussing these issues with my Dr. this week. It is such a blessing to have a support group to rely on!! ---
**Author:** ![GwynnethP](https://sea1.discourse-cdn.com/flex019/user_avatar/discussion.livingwithpsoriaticarthritis.org/gwynnethp/32/382_2.png) [@GwynnethP](https://discussion.livingwithpsoriaticarthritis.org/u/GwynnethP)\ **Post date:** [January 3, 2013, 7:51pm UTC](https://discussion.livingwithpsoriaticarthritis.org/t/methotrexate-questions/1284/10 "2013-01-03T19:51:05Z")
Like marg above, I’m on 25mg and have no itching. Contact your doc if I were you.