Autoimmune arthritis / family connection

I'm not sure who would have this kind of information.

But here's a twist. In 2010 I was diagnosed with psoriatic arthritis. Last month I did a full physical check up with my regular doctor; she did blood test and one of them was for auto immune, results: negative. I'm not sure what to make of this.

Interesting, Marietta. You’d have to know more about genetics than I do to know the answer to that one!

What I do know is that at the Toronto PsA research clinic they are doing a lot of research into the genetics of the disease, and they are really really interested in my relatives’ health. The last time I was there, I answered what seemed like hundreds of questions about my parents and my sister. But nothing further back than that: the person they were most interested in was my sister.

Such a good question!

My sister was just recently diagnosed. She was told because of her family history, her rheumatologist had no doubt that she also had PSA. There must be some link? We have a long list of arthritis and other auto immune in our family. My mom, uncle, aunts, cousins, second cousins (all on my mom's side) have been diagnosed with.... arthritis both Osteo and Auto immune, spondylitis, Chron's , Fibromyalgia , Ehlers Danlos-Syndrome and Juvenile Arthritis.

My dad has psoriasis and RA. Sometimes I wonder if it's not PSA he has, as he has spine involvement just like me. My maternal aunt has psoriasis and has had what the docs have said osteo in her spine since she was 21, it is in a lot of her body now. I told her about PSA and told her to tell her doctor about it, I really hope she does.

My other maternal aunt had reactive arthritis when she was in her early 30s.

I'm the only one out of my siblings and I that have arthritis problems so far, but both my sisters are in their early 30s so there is still lots of time.

I've been tested by my doc for HLA-B15 and came out negative.

It simply means that you're seronegative. It can make it more challenging for diagnosis, but that doesn't mean that the diagnosis is incorrect. You're in decent shape, as you've already received a diagnosis.

Welcome to the club!


Max said:

I'm not sure who would have this kind of information.

But here's a twist. In 2010 I was diagnosed with psoriatic arthritis. Last month I did a full physical check up with my regular doctor; she did blood test and one of them was for auto immune, results: negative. I'm not sure what to make of this.

Blood tests aren't always indicative. I should know, I had my ANA tested every 6 months for several years with consistently negative results. My Dermatologist insisted on including the ANA with the rest of my bloodwork when I was on Humira. Once I began seeing a Rheumy, I had a complete blood workup - and every single blood test that is indicative of an autoimmune disorder was negative. According to my blood, even my inflammation is nonexistent (which is silly considering my bursa in my left knee is roughly 4x its "normal" size).

YUP!
My blood work has been nothing alarming. My CRP has gone up a teeny bit but still in the normal zone



tmbrwolf329 said:

Blood tests aren’t always indicative. I should know, I had my ANA tested every 6 months for several years with consistently negative results. My Dermatologist insisted on including the ANA with the rest of my bloodwork when I was on Humira. Once I began seeing a Rheumy, I had a complete blood workup - and every single blood test that is indicative of an autoimmune disorder was negative. According to my blood, even my inflammation is nonexistent (which is silly considering my bursa in my left knee is roughly 4x its “normal” size).